Functional immunogenetic variation, rather than local adaptation, predicts ectoparasite infection intensity in a model fish species

Phillips, Karl P., Cable, Joanne, Mohammed, Ryan S., Chmielewski, Sebastian, Przesmycka, Karolina J., Van Oosterhout, Cock and Radwan, Jacek (2021) Functional immunogenetic variation, rather than local adaptation, predicts ectoparasite infection intensity in a model fish species. Molecular Ecology. ISSN 0962-1083

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Abstract

Natural host populations differ in their susceptibility to infection by parasites, and these intrapopulation differences are still an incompletely understood component of host-parasite dynamics. In this study, we used controlled infection experiments with wild-caught guppies (Poecilia reticulata) and their ectoparasite Gyrodactylus turnbulli to investigate the roles of local adaptation and host genetic composition (immunogenetic and neutral) in explaining differences in susceptibility to infection. We found differences between our four study host populations that were consistent between two parasite source populations, with no indication of local adaptation by either host or parasite at two tested spatial scales. Greater values of host population genetic variability metrics broadly aligned with lower population mean infection intensity, with the best alignments associated with major histocompatibility complex (MHC) “supertypes”. Controlling for intrapopulation differences and potential inbreeding variance, we found a significant negative relationship between individual-level functional MHC variability and infection: fish carrying more MHC supertypes experienced infections of lower severity, with limited evidence for supertype-specific effects. We conclude that population-level differences in host infection susceptibility probably reflect variation in parasite selective pressure and/or host evolutionary potential, underpinned by functional immunogenetic variation.

Item Type: Article
Uncontrolled Keywords: gyrodactylus,mhc supertypes,poecilia reticulata,host-parasite coevolution,major histocompatibility complex,ecology, evolution, behavior and systematics,genetics ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School: Faculty of Science > School of Environmental Sciences
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Depositing User: LivePure Connector
Date Deposited: 11 Sep 2021 00:18
Last Modified: 16 Sep 2021 11:15
URI: https://ueaeprints.uea.ac.uk/id/eprint/81391
DOI: 10.1111/mec.16135

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