Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls

Gwinnutt, James M., Toyoda, Task, Jeffs, Stephen, Flanagan, Emma, Chipping, Jacqueline R., Dainty, Jack R., Mioshi, Eneida, Hornberger, Michael and MacGregor, Alex (2021) Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls. Rheumatology Advances in Practice, 5 (2). ISSN 2514-1775

[img] PDF (Published_Version) - Published Version
Available under License Creative Commons Attribution.

Download (232kB)

Abstract

Objective: The aim was to compare the cognitive ability of people with RA with healthy controls (HCs). Methods: People with RA were recruited from the Norfolk Arthritis Register (NOAR), a population-based cohort study of people with inflammatory arthritis. Data on aged-matched HCs (people with no cognitive impairment) came from the comparison arm of The Dementia Research and Care Clinic Study (TRACC). People with RA and HCs performed a range of cognitive ability tasks to assess attention, memory, verbal fluency, language, visuospatial skills, emotional recognition, executive function and theory of mind. A score of <88 on the Addenbrooke’s Cognitive Examination III was considered cognitive impairment. Scores were compared using linear regression adjusting for age, sex, smoking status, education, BMI, anxiety and depression. Results: Thirty-eight people with RA [mean (S.D.) age: 69.1 (8.0) years; 25 (65.8%) women] were matched with 28 HCs [mean (S.D.) age: 68.2 (6.4) years; 15 (53.6%) women]. Twenty-three (60.5%) people with RA were considered to have mild cognitive impairment [mean (S.D.) Addenbrooke’s Cognitive Examination III: RA = 85.2 (7.4), HC = 96.0 (2.5)]. People with RA had impairments in memory, verbal fluency, visuospatial functioning, executive function and emotional recognition in faces compared with HCs, after adjustment for confounders. Conclusion: People with RA had cognitive impairments in a range of domains. People with RA might benefit from cognitive impairment screening to allow for early administration of appropriate interventions.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 08 Sep 2021 02:00
Last Modified: 16 Sep 2021 11:14
URI: https://ueaeprints.uea.ac.uk/id/eprint/81324
DOI: 10.1093/rap/rkab044

Actions (login required)

View Item View Item