Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls

Gwinnutt, James M., Toyoda, Task, Jeffs, Stephen, Flanagan, Emma, Chipping, Jacqueline R., Dainty, Jack R., Mioshi, Eneida, Hornberger, Michael and MacGregor, Alex (2021) Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls. Rheumatology Advances in Practice, 5 (2). ISSN 2514-1775

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Abstract

Objective: The aim was to compare the cognitive ability of people with RA with healthy controls (HCs). Methods: People with RA were recruited from the Norfolk Arthritis Register (NOAR), a population-based cohort study of people with inflammatory arthritis. Data on aged-matched HCs (people with no cognitive impairment) came from the comparison arm of The Dementia Research and Care Clinic Study (TRACC). People with RA and HCs performed a range of cognitive ability tasks to assess attention, memory, verbal fluency, language, visuospatial skills, emotional recognition, executive function and theory of mind. A score of <88 on the Addenbrooke’s Cognitive Examination III was considered cognitive impairment. Scores were compared using linear regression adjusting for age, sex, smoking status, education, BMI, anxiety and depression. Results: Thirty-eight people with RA [mean (S.D.) age: 69.1 (8.0) years; 25 (65.8%) women] were matched with 28 HCs [mean (S.D.) age: 68.2 (6.4) years; 15 (53.6%) women]. Twenty-three (60.5%) people with RA were considered to have mild cognitive impairment [mean (S.D.) Addenbrooke’s Cognitive Examination III: RA = 85.2 (7.4), HC = 96.0 (2.5)]. People with RA had impairments in memory, verbal fluency, visuospatial functioning, executive function and emotional recognition in faces compared with HCs, after adjustment for confounders. Conclusion: People with RA had cognitive impairments in a range of domains. People with RA might benefit from cognitive impairment screening to allow for early administration of appropriate interventions.

Item Type:	Article
Additional Information:	Funding Information: This work was supported by the Medical Research Council (through a Skills Development Fellowship for J.M.G.) and Versus Arthritis (grant numbers 20385, 20380). TRACC was supported by the UEA Faculty of Medicine and Health Sciences and the Norfolk and Suffolk Foundation Trust.
Uncontrolled Keywords:	attention,cognition,executive function,memory,mental health,psychology,rheumatoid arthritis,rheumatology ,/dk/atira/pure/subjectarea/asjc/2700/2745
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Centres > Population Health
Related URLs:	http://www.scopus.com/inward/record.url?... https://academic.oup.com/rheumap/article...
Depositing User:	LivePure Connector
Date Deposited:	08 Sep 2021 02:00
Last Modified:	28 Mar 2025 10:54
URI:	https://ueaeprints.uea.ac.uk/id/eprint/81324
DOI:	10.1093/rap/rkab044

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