Autophagy impairment by African swine fever virus

Shimmon, Gareth L., Hui, Joshua Y. K., Wileman, Thomas E. and Netherton, Christopher L. (2021) Autophagy impairment by African swine fever virus. Journal of General Virology, 102 (8). ISSN 0022-1317

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Abstract

African swine fever is a devastating disease of domestic swine and wild boar caused by a large double-stranded DNA virus that encodes for more than 150 open reading frames. There is no licensed vaccine for the disease and the most promising current candidates are modified live viruses that have been attenuated by deletion of virulence factors. Like many viruses African swine fever virus significantly alters the host cell machinery to benefit its replication and viral genes that modify host pathways represent promising targets for development of gene deleted vaccines. Autophagy is an important cellular pathway that is involved in cellular homeostasis, innate and adaptive immunity and therefore is manipulated by a number of different viruses. Autophagy is regulated by a complex protein cascade and here we show that African swine fever virus can block formation of autophagosomes, a critical functional step of the autophagy pathway through at least two different mechanisms. Interestingly this does not require the A179L gene that has been shown to interact with Beclin-1, an important autophagy regulator.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 25 Aug 2021 09:55
Last Modified: 18 Sep 2021 01:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/81207
DOI: 10.1099/jgv.0.001637

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