An age-specific atlas for delineation of white matter pathways in children aged 6-8 years

Spencer, Arthur P. C., Byrne, Hollie, Lee-Kelland, Richard, Jary, Sally, Thoresen, Marianne, Cowan, Frances M., Chakkarapani, Ela and Brooks, Jonathan C. W. ORCID: (2022) An age-specific atlas for delineation of white matter pathways in children aged 6-8 years. Brain Connectivity, 12 (5). pp. 402-416. ISSN 2158-0014

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Introduction: Diffusion magnetic resonance imaging (MRI) allows noninvasive assessment of white matter connectivity in typical development and of changes due to brain injury or pathology. Probabilistic white matter atlases allow diffusion metrics to be measured in specific white matter pathways, and are a critical component in spatial normalization for group analysis. However, given the known developmental changes in white matter it may be suboptimal to use an adult template when assessing data acquired from children. Methods: By averaging subject-specific fiber bundles from 28 children aged from 6 to 8 years, we created an age-specific probabilistic white matter atlas for 12 major white matter tracts. Using both the newly developed and Johns Hopkins adult atlases, we compared the atlas with subject-specific fiber bundles in two independent validation cohorts, assessing accuracy in terms of volumetric overlap and measured diffusion metrics. Results: Our age-specific atlas gave better overall performance than the adult atlas, achieving higher volumetric overlap with subject-specific fiber tracking and higher correlation of fractional anisotropy (FA) measurements with those measured from subject-specific fiber bundles. Specifically, estimates of FA values for corticospinal tract, uncinate fasciculus, forceps minor, cingulate gyrus part of the cingulum, and anterior thalamic radiation were all significantly more accurate when estimated with an age-specific atlas. Discussion: The age-specific atlas allows delineation of white matter tracts in children aged 6-8 years, without the need for tractography, more accurately than when normalizing to an adult atlas. To our knowledge, this is the first publicly available probabilistic atlas of white matter tracts for this age group.

Item Type: Article
Additional Information: Funding Information: This work was supported by the Baily Thomas Charitable Fund [grant number TRUST/VC/AC/SG4681-7596]. A.P.C.S. is supported by the Wellcome Trust [grant number 220070/ Z/20/Z]. J.C.W.B. is supported by the UK Medical Research Council [grant number MR/N026969/1]. This research was funded in whole, or in part, by the Wellcome Trust [grant number 220070/Z/20/Z]. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Uncontrolled Keywords: atlas,diffusion mri,tractography,white matter,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 25 Aug 2021 09:53
Last Modified: 25 Oct 2022 10:30
DOI: 10.1089/brain.2021.0058

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