Changes in mental state and behaviour in Huntington's disease

Eddy, Clare M., Parkinson, Ellice ORCID: and Rickards, Hugh E. (2016) Changes in mental state and behaviour in Huntington's disease. The Lancet Psychiatry, 3 (11). pp. 1079-1086. ISSN 2215-0366

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Changes in mental state and behaviour have been acknowledged in Huntington's disease since the original monograph in 1872 provided evidence of disinhibition and impaired social cognition. Behavioural problems can manifest before obvious motor symptoms and are frequently the most disabling part of the illness. Although pharmacological treatments are used routinely for psychiatric difficulties in Huntington's disease, the scientific evidence base for their use is somewhat sparse. Moreover, effective treatments for apathy and cognitive decline do not currently exist. Understanding the social cognitive impairments associated with Huntington's disease can assist management, but related therapeutic interventions are needed. Future research should aim to design rating scales for behaviour and mental state in Huntington's disease that can detect change in clinical trials. Generally, communication and understanding of behaviour and mental state in Huntington's would be enhanced by a clear conceptual framework that unifies ideas around movement, cognition, emotion, behaviour, and mental state, reflecting both the experience of the patient and their underlying neuropathology.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User: LivePure Connector
Date Deposited: 14 Aug 2021 00:26
Last Modified: 23 Oct 2022 02:50
DOI: 10.1016/S2215-0366(16)30144-4

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