Importance of tyrosine phosphorylation for transmembrane signaling in plants

Mühlenbeck, Henning, Bender, Kyle W. and Zipfel, Cyril (2021) Importance of tyrosine phosphorylation for transmembrane signaling in plants. Biochemical Journal, 478 (14). pp. 2759-2774. ISSN 0264-6021

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Abstract

Reversible protein phosphorylation is a widespread post-translational modification fundamental for signaling across all domains of life. Tyrosine (Tyr) phosphorylation has recently emerged as being important for plant receptor kinase (RK)-mediated signaling, particularly during plant immunity. How Tyr phosphorylation regulates RK function is however largely unknown. Notably, the expansion of protein Tyr phosphatase and SH2 domain-containing protein families, which are the core of regulatory phospho-Tyr (pTyr) networks in choanozoans, did not occur in plants. Here, we summarize the current understanding of plant RK Tyr phosphorylation focusing on the critical role of a pTyr site (‘VIa-Tyr’) conserved in several plant RKs. Furthermore, we discuss the possibility of metazoan-like pTyr signaling modules in plants based on atypical components with convergent biochemical functions.

Item Type: Article
Uncontrolled Keywords: biochemistry,molecular biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1303
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Depositing User: LivePure Connector
Date Deposited: 30 Jul 2021 00:10
Last Modified: 31 Aug 2021 00:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/80905
DOI: 10.1042/BCJ20210202

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