Causes and consequences of telomere lengthening in a wild vertebrate population

Brown, Thomas J., Spurgin, Lewis G., Dugdale, Hannah L., Komdeur, Jan, Burke, Terry and Richardson, David S. ORCID: (2022) Causes and consequences of telomere lengthening in a wild vertebrate population. Molecular Ecology, 31 (23). pp. 5933-5945. ISSN 0962-1083

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Telomeres have been advocated to be important markers of biological age in evolutionary and ecological studies. Telomeres usually shorten with age and shortening is frequently associated with environmental stressors and increased subsequent mortality. Telomere lengthening – an apparent increase in telomere length between repeated samples from the same individual – also occurs. However, the exact circumstances, and consequences, of telomere lengthening are poorly understood. Using longitudinal data from the Seychelles warbler (Acrocephalus sechellensis), we tested whether telomere lengthening – which occurs in adults of this species – is associated with specific stressors (reproductive effort, food availability, malarial infection and cooperative breeding) and predicts subsequent survival. In females, telomere shortening was observed under greater stress (i.e., low food availability, malaria infection), while telomere lengthening was observed in females experiencing lower stress (i.e., high food availability, assisted by helpers, without malaria). The telomere dynamics of males were not associated with the key stressors tested. These results indicate that, at least for females, telomere lengthening occurs in circumstances more conducive to self-maintenance. Importantly, both females and males with lengthened telomeres had improved subsequent survival relative to individuals that displayed unchanged, or shortened, telomeres – indicating that telomere lengthening is associated with individual fitness. These results demonstrate that telomere dynamics are bidirectionally responsive to the level of stress that an individual faces, but may poorly reflect the accumulation of stress over an individuals lifetime.

Item Type: Article
Additional Information: Special Issue: TELOMERES IN ECOLOGY AND EVOLUTION Research Funding: Nederlandse Organisatie voor Wetenschappelijk Onderzoek. Grant Numbers: 823.01.014, 854.11.003, NE/I021748/1, NER/I/S/2002/00712, NWO-ALW 823.01.014 Natural Environment Research Council. Grant Numbers: NE/F02083X/1, NE/K005502/1 Biotechnology and Biological Sciences Research Council. Grant Number: BB/M011216/1
Uncontrolled Keywords: ageing,biomarkers,life-history,senescence,stress,telomeres,vertebrates,wild populations,ecology, evolution, behavior and systematics,genetics,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation
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Depositing User: LivePure Connector
Date Deposited: 24 Jul 2021 00:10
Last Modified: 08 Mar 2024 14:30
DOI: 10.1111/mec.16059

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