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Arthurs, Ross A., Dean, Alice C., Hughes, David L. and Richards, Christopher J. 
ORCID: https://orcid.org/0000-0001-7899-4082
(2021)
Copper(I) complexes of P-stereogenic Josiphos and related ligands.
European Journal of Organic Chemistry, 2021 (18).
pp. 2719-2725.
ISSN 1434-193X
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Abstract
Starting from (R)-Ugi's amine, diastereoselective lithiation followed by Ar'PCl 2 and then Ar’’MgBr led to the generation, as single diastereoisomers, of (R,S p,S phos) [Ar’=Ph, Ar’’=o-Tol] and (R,S p,R phos) [Ar’=o-Tol, Ar’’=Ph] PPFA ligand derivatives. Amine substitution of both with HPCy 2 gave P-stereogenic Josiphos ligands, and then addition of CuCl, the corresponding copper(I) complexes. The latter were also generated by using borane P and N protecting groups and in situ Cu(I) complexation, avoiding the isolation of air-sensitive phosphine intermediates. This protection methodology was also applied to the synthesis of Josiphos/CuCl complexes derived from PCl 3. In addition, related bulky cobalt-sandwich complex-based derivatives were also obtained. Preliminary investigation revealed isolated CuCl complexes as competent catalyst precursors for enantioselective conjugate addition reactions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | asymmetric catalysis,copper,ligand design,metallocene,protecting groups,physical and theoretical chemistry,organic chemistry,2* ,/dk/atira/pure/subjectarea/asjc/1600/1606 |
| Faculty \ School: | Faculty of Science > School of Chemistry |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemistry of Materials and Catalysis |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Jul 2021 01:10 |
| Last Modified: | 24 Oct 2022 06:45 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/80384 |
| DOI: | 10.1002/ejoc.202100146 |
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