Do statins reduce mortality in older people? Findings from a longitudinal study using primary care records

Gitsels, Lisanne, Bakbergenuly, Ilyas, Steel, Nicholas ORCID: and Kulinskaya, Elena (2021) Do statins reduce mortality in older people? Findings from a longitudinal study using primary care records. Family Medicine and Community Health, 9 (2). ISSN 2305-6983

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Objective: Assess whether statins reduce mortality in the general population aged 60 years and above. Design Retrospective cohort study. Setting Primary care practices contributing to The Health Improvement Network database, England and Wales, 1990-2017. Participants Cohort who turned age 60 between 1990 and 2000 with no previous cardiovascular disease or statin prescription and followed up until 2017. Results Current statin prescription was associated with a significant reduction in all-cause mortality from age 65 years onward, with greater reductions seen at older ages. The adjusted HRs of mortality associated with statin prescription at ages 65, 70, 75, 80 and 85 years were 0.76 (95% CI 0.71 to 0.81), 0.71 (95% CI 0.68 to 0.75), 0.68 (95% CI 0.65 to 0.72), 0.63 (95% CI 0.53 to 0.73) and 0.54 (95% CI 0.33 to 0.92), respectively. The adjusted HRs did not vary by sex or cardiac risk. Conclusions Using regularly updated clinical information on sequential treatment decisions in older people, mortality predictions were updated every 6 months until age 85 years in a combined primary and secondary prevention population. The consistent mortality reduction of statins from age 65 years onward supports their use where clinically indicated at age 75 and older, where there has been particular uncertainty of the benefits.

Item Type: Article
Uncontrolled Keywords: cardiovascular diseases,epidemiology,health records,personal,public health, environmental and occupational health,family practice,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2739
Faculty \ School: Faculty of Science > School of Computing Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 28 May 2021 00:34
Last Modified: 23 Oct 2022 02:30
DOI: 10.1136/fmch-2020-000780

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