Drug coated balloons for coronary artery bifurcation lesions: a systematic review and focused meta-analysis

Corballis, Natasha H., Paddock, Sophie, Gunawardena, Tharusha, Merinopoulos, Ioannis, Vassiliou, Vassilios and Eccleshall, Simon C. (2021) Drug coated balloons for coronary artery bifurcation lesions: a systematic review and focused meta-analysis. PLoS One, 16 (7). ISSN 1932-6203

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Objectives We sought to systematically review the evidence supporting the role of drug coated balloons (DCBs) in the treatment of coronary bifurcation lesions. Background DCBs are emerging as an attractive alternative treatment strategy for treating coronary bifurcations due to simplifying the approach and reducing rates of stent related complications. We systematically reviewed the evidence for DCB use in coronary bifurcations and conducted a focused meta-analysis on late lumen loss in the side branch comparing DCB and plain old balloon angioplasty (POBA). Methods This study was conducted in line with the PRISMA statement. All studies (including both RCTs and observational studies, excluding case reports) using DCB as part of a bifurcation strategy were included in this review. A literature search identified a total of ten studies for inclusion. A focused meta-analysis was undertaken for the use of DCB in side-branch compared with POBA. Mean late lumen loss was used with a random effects model due to heterogeneity. Results DCB was found to be superior to POBA for side branch treatment in bifurcations (p = 0.01). There are four studies that investigated the use of DCB for main branch treatment in a bifurcation, with evidence supporting its safety in main branches of bifurcation lesions, while prospective observational studies have demonstrated favourable target lesion revascularisation rates. Conclusion Although there is a lack of robust RCTs comparing DCBs with current generation DES, DCBs appear safe in main branch bifurcation lesions with improved side branch late lumen loss when compared with DES or POBA.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 28 May 2021 00:33
Last Modified: 10 Oct 2021 00:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/80149
DOI: 10.1371/journal.pone.0251986

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