DDX3X suppresses the susceptibility of hindbrain lineages to medulloblastoma

Patmore, Deanna M., Jassim, Amir, Nathan, Erica, Gilbertson, Reuben J., Tahan, Daniel, Hoffmann, Nadin, Tong, Yiai, Smith, Kyle S., Kanneganti, Thirumala-Devi, Suzuki, Hiromichi, Taylor, Michael D., Northcott, Paul and Gilbertson, Richard J. (2020) DDX3X suppresses the susceptibility of hindbrain lineages to medulloblastoma. Developmental Cell, 54 (4). 455-470.e5. ISSN 1534-5807

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Abstract

DEAD-Box Helicase 3 X-Linked (DDX3X) is frequently mutated in the Wingless (WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma—the commonest malignant childhood brain tumor, but whether DDX3X functions as a medulloblastoma oncogene or tumor suppressor gene is not known. Here, we show that Ddx3x regulates hindbrain patterning and development by controlling Hox gene expression and cell stress signaling. In mice predisposed to Wnt- or Shh medulloblastoma, Ddx3x sensed oncogenic stress and suppressed tumor formation. WNT and SHH medulloblastomas normally arise only in the lower and upper rhombic lips, respectively. Deletion of Ddx3x removed this lineage restriction, enabling both medulloblastoma subtypes to arise in either germinal zone. Thus, DDX3X is a medulloblastoma tumor suppressor that regulates hindbrain development and restricts the competence of cell lineages to form medulloblastoma subtypes.

Item Type: Article
Uncontrolled Keywords: ddx3x,hox genes,inflammasome,medulloblastoma,stress granule,tumor suppressor gene,molecular biology,biochemistry, genetics and molecular biology(all),developmental biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1312
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Depositing User: LivePure Connector
Date Deposited: 15 May 2021 00:12
Last Modified: 18 Aug 2021 11:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/80021
DOI: 10.1016/j.devcel.2020.05.027

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