Evolution of diverse strategies for promoter regulation

Brázda, Václav, Bartas, Martin and Bowater, Richard P. ORCID: https://orcid.org/0000-0002-2745-7807 (2021) Evolution of diverse strategies for promoter regulation. Trends in Genetics, 37 (8). pp. 730-744. ISSN 0168-9525

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DNA is fundamentally important for all cellular organisms due to its role as a store of hereditary genetic information. The precise and accurate regulation of gene transcription depends primarily on promoters, which vary significantly within and between genomes. Some promoters are rich in specific types of bases, while others have more varied, complex sequence characteristics. However, it is not only base sequence but also epigenetic modifications and altered DNA structure that regulate promoter activity. Significantly, many promoters across all organisms contain sequences that can form intrastrand hairpins (cruciforms) or four-stranded structures (G-quadruplex or i-motif). In this review we integrate recent studies on promoter regulation that highlight the importance of DNA structure in the evolutionary adaptation of promoter sequences.

Item Type: Article
Uncontrolled Keywords: dna base sequence,dna structure,epigenetics,evolution,promoters,transcription,genetics ,/dk/atira/pure/subjectarea/asjc/1300/1311
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Biosciences Teaching and Education Research
Faculty of Science > Research Groups > Molecular Microbiology
Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
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Depositing User: LivePure Connector
Date Deposited: 14 Apr 2021 23:53
Last Modified: 21 Apr 2023 01:00
URI: https://ueaeprints.uea.ac.uk/id/eprint/79765
DOI: 10.1016/j.tig.2021.04.003

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