Tools
Tools
Woodcock, Dan, Riabchenko, Ekaterina, Taavitsainen, Sinja, Kankainen, Matti, Gundem, Gunes, Brewer, Daniel 
ORCID: https://orcid.org/0000-0003-4753-9794, Ellonen, Pekka, Lepistö, Maija, Golubeva, Yelena, Warner, Andrew, Tolonen, Teemu, Jasu, Juho, Isaacs, William B., Emmert-Buck, Michael R., Nykter, Matti, Visakorpi, Tapio, Bova, G. Steven and Wedge, David C.
(2020)
Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy.
Nature Communications, 11.
ISSN 2041-1723
Preview |
PDF (Published_Version)
- Published Version
Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tumor DNA extracted from blood and cerebrospinal fluid. Substantial evolution occurs within the prostate, resulting in branching into multiple spatially intermixed lineages. One dominant lineage emerges that initiates and drives systemic metastasis, where polyclonal seeding between sites is common. Routes to metastasis differ between patients, and likely genetic drivers of metastasis distinguish the metastatic lineage from the lineage that remains confined to the prostate within each patient. Body fluids only capture features of the dominant lineage, and subclonal expansions that occur in the metastatic phase are non-uniformly represented. Cerebrospinal fluid analysis reveals lineages not detected in blood-borne DNA, suggesting possible clinical utility.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 13 Apr 2021 23:46 |
| Last Modified: | 19 Oct 2023 02:48 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/79707 |
| DOI: | 10.1038/s41467-020-18843-5 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |