The Fur-like protein Mur of Rhizobium leguminosarum is a Mn2+ responsive transcriptional regulator

Diaz-Mireles, E., Wexler, M., Sawers, G., Bellini, D., Todd, J. D. and Johnston, A. W. B. (2004) The Fur-like protein Mur of Rhizobium leguminosarum is a Mn2+ responsive transcriptional regulator. Microbiology, 150 (5). pp. 1447-1456. ISSN 1465-2080

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Abstract

In wild-type Rhizobium leguminosarum, the sitABCD operon specifies a Mn2+ transporter whose expression is severely reduced in cells grown in the presence of this metal. Mutations in the R. leguminosarum gene, mur (manganese uptake regulator), whose product resembles the Fur transcriptional regulator, cause high-level expression of sitABCD in the presence of Mn2+. In gel-shift mobility assays, purified R. leguminosarum Mur protein bound to at least two regions near the sitABCD promoter region, although this DNA has no conventional consensus Fur-binding sequences (fur boxes). Thus, in contrast to γ-proteobacteria, where Fur binds Fe2+, the R. leguminosarum Fur homologue, Mur, act as a Mn2-responsive transcriptional regulator.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Molecular Microbiology
Depositing User: EPrints Services
Date Deposited: 01 Oct 2010 13:37
Last Modified: 14 Jul 2024 00:00
URI: https://ueaeprints.uea.ac.uk/id/eprint/796
DOI: 10.1099/mic.0.26961-0

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