2D and 3D inkjet printing of biopharmaceuticals – A review of trends and future perspectives in research and manufacturing

Evans, Susannah Elizabeth, Harrington, Tomás, Rodriguez Rivero, Maria Cristina, Rognin, Etienne, Tuladhar, Tri and Daly, Ronan (2021) 2D and 3D inkjet printing of biopharmaceuticals – A review of trends and future perspectives in research and manufacturing. International Journal of Pharmaceutics, 599. ISSN 0378-5173

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Abstract

There is an ongoing global shift in pharmaceutical business models from small molecule drugs to biologics. This increase in complexity is in response to advancements in our diagnoses and understanding of diseases. With the more targeted approach coupled with its inherently more costly development and manufacturing, 2D and 3D printing are being explored as suitable techniques to deliver more personalised and affordable routes to drug discovery and manufacturing. In this review, we explore first the business context underlying this shift to biopharmaceuticals and provide an update on the latest work exploring discovery and pharmaceutics. We then draw on multiple disciplines to help reveal the shared challenges facing researchers and firms aiming to develop biopharmaceuticals, specifically when using the most commonly explored manufacturing routes of drop-on-demand inkjet printing and pneumatic extrusion. This includes separating out how to consider mechanical and chemical influences during manufacturing, the role of the chosen hardware and the challenges of aqueous formulation based on similar challenges being faced by the printing industry. Together, this provides a review of existing work and guidance for researchers and industry to help with the de-risking and rapid development of future biopharmaceutical products.

Item Type: Article
Faculty \ School: Faculty of Social Sciences > Norwich Business School
Depositing User: LivePure Connector
Date Deposited: 02 Mar 2021 01:03
Last Modified: 21 Jul 2021 01:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/79345
DOI: 10.1016/j.ijpharm.2021.120443

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