Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study

Grootswagers, Pol, Mensink, Marco, Berendsen, Agnes A. M., Deen, Carolien P. J., Kema, Ido P., Bakker, Stephan J. L., Santoro, Aurelia, Franceschi, Claudio, Meunier, Nathalie, Malpuech-Brugère, Corinne, Bialecka-Debek, Agata, Rolf, Katarzyna, Fairweather-Tait, Susan, Jennings, Amy, Feskens, Edith J. M. and De groot, Lisette C. P. G. M. (2021) Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study. The American Journal of Clinical Nutrition, 113 (4). 781–789. ISSN 0002-9165

[img]
Preview
PDF (Published_Version) - Published Version
Available under License Creative Commons Attribution.

Download (201kB) | Preview

Abstract

BACKGROUND: Maintenance of high physical performance during aging might be supported by an adequate dietary intake of niacin, vitamins B-6 and B-12, and folate because these B vitamins are involved in multiple processes related to muscle functioning. However, not much is known about the association between dietary intake of these B vitamins and physical performance. OBJECTIVES: The objectives of this study were to investigate the association between dietary intake of niacin, vitamins B-6 and B-12, and folate and physical performance in older adults and to explore mediation by niacin status and homocysteine concentrations. METHODS: We used baseline data from the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) trial, which included n = 1249 healthy older adults (aged 65-79 y) with complete data on dietary intake measured with 7-d food records and questionnaires on vitamin supplement use and physical performance measured with the short physical performance battery and handgrip dynamometry. Associations were assessed by adjusted linear mixed models. RESULTS: Intake of vitamin B-6 was related to lower chair rise test time [β: -0.033 ± 0.016 s (log); P = 0.043]. Vitamin B-6 intake was also significantly associated with handgrip strength, but for this association, a significant interaction effect between vitamin B-6 intake and physical activity level was found. In participants with the lowest level of physical activity, higher intake of vitamin B-6 tended to be associated with greater handgrip strength (β: 1.5 ± 0.8 kg; P = 0.051), whereas in participants in the highest quartile of physical activity, higher intake was associated with lower handgrip strength (β: -1.4 ± 0.7 kg; P = 0.041). No evidence was found for an association between intake of niacin, vitamin B-12, or folate and physical performance or for mediation by niacin status or homocysteine concentrations. CONCLUSIONS: Vitamin B-6 intake was associated with better chair rise test time in a population of European healthy older adults and also with greater handgrip strength in participants with low physical activity only. Homocysteine concentrations did not mediate these associations. The NU-AGE trial was registered at clinicaltrials.gov as NCT01754012.

Item Type: Article
Uncontrolled Keywords: folate,homocysteine,muscle,niacin,physical function,vitamin b-12,vitamin b-6,medicine (miscellaneous),nutrition and dietetics ,/dk/atira/pure/subjectarea/asjc/2700/2701
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 03 Feb 2021 00:59
Last Modified: 30 Sep 2021 16:12
URI: https://ueaeprints.uea.ac.uk/id/eprint/79147
DOI: 10.1093/ajcn/nqaa368

Actions (login required)

View Item View Item