Expression analysis of chick Frizzled receptors during spinal cord development

Alrefaei, Abdulmajeed Fahad, Münsterberg, Andrea E. ORCID: and Wheeler, Grant N. ORCID: (2021) Expression analysis of chick Frizzled receptors during spinal cord development. Gene Expression Patterns, 39. ISSN 1567-133X

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Frizzleds (Fzds) are transmembrane receptors that can transduce signals dependent upon binding of Wnts, a large family of secreted glycoproteins homologous to the Drosophila wingless gene. FZDs are critical for a wide variety of normal and pathological developmental processes. In the nervous system, Wnts and Frizzleds play an important role in anterior-posterior patterning, cell fate decisions, proliferation, and synaptogenesis. Here, we preformed a comprehensive expression profile of Wnt receptors (FZD) by using situ hybridization to identify FZDs that are expressed in dorsal-ventral regions of the neural tube development. Our data show specific expression for FZD1,2,3,7,9 and 10 in the chick developing spinal cord. This expression profile of cFZD receptors offers the basis for functional studies in the future to determine roles for the different FZD receptors and their interactions with Wnts during dorsal-ventral neural tube development in vivo. Furthermore, we also show that co-overexpression of Wnt1/3a by in vivo electroporation affects FZD7/10 expression in the neural tube. This illustrates an example of Wnts-FZDs interactions during spinal cord neurogenesis.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Cells and Tissues
Faculty of Science > Research Groups > Wheeler Group
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Depositing User: LivePure Connector
Date Deposited: 20 Jan 2021 00:57
Last Modified: 20 Apr 2023 19:36
DOI: 10.1016/j.gep.2021.119167

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