Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines

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Maujean, Timothé, Girard, Nicolas, Ganesan, A. ORCID: https://orcid.org/0000-0003-4862-7999, Gulea, Mihaela and Bonnet, Dominique (2020) Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines. RSC Advances, 10 (71). pp. 43358-43370. ISSN 2046-2069

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Abstract

Nitrogen-containing heterocycles represent a major source of pharmacological probes and drug candidates. To extend their molecular diversity and their potential biological activities, it is of importance to design and synthesize new N-heterocyclic scaffolds. Therefore, aza-diketopiperazines (aza-DKPs), the aza analogues of well-known 2,5-diketopiperazines (DKPs), emerged as a promising new scaffold. Although the first synthesis of an aza-DKP dates from 1951, significant developments have been made during the last decade. This feature article summarizes the different synthetic strategies to access and functionalise aza-DKPs. Their biological properties and potential applications in medicinal chemistry and drug discovery are discussed as well.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://www.scopus.com/inward/record.url?... http://xlink.rsc.org/?DOI=D0RA09457A
Depositing User:	LivePure Connector
Date Deposited:	09 Jan 2021 01:22
Last Modified:	22 Oct 2022 07:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/78133
DOI:	10.1039/D0RA09457A

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