How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence

Stretton, Jason, Walsh, Nicholas D., Mobbs, Dean, Schweizer, Susanne, van Harmelen, Anne-Laura, Lombardo, Michael, Goodyer, Ian and Dalgleish, Tim (2021) How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence. Brain and Behavior, 11 (5). ISSN 2162-3279

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Abstract

Introduction: Understanding the emotional responsivity style and neurocognitive profiles of depression‐related processes in at‐risk youth may be helpful in revealing those most likely to develop affective disorders. However, the multiplicity of biopsychosocial risk factors makes it difficult to disentangle unique and combined effects at a neurobiological level. Methods: In a population‐derived sample of 56 older adolescents (aged 17–20), we adopted partial least squares regression and correlation models to explore the relationships between multivariate biopsychosocial risks for later depression, emotional response style, and fMRI activity, to rejecting and inclusive social feedback. Results: Behaviorally, higher depressive risk was associated with both reduced negative affect following negative social feedback and reduced positive affect following positive social feedback. In response to both cues of rejection and inclusion, we observed a general neural pattern of increased cingulate, temporal, and striatal activity in the brain. Secondly, in response to rejection only, we observed a pattern of activity in ostensibly executive control‐ and emotion regulation‐related brain regions encompassing fronto‐parietal brain networks including the angular gyrus. Conclusion: The results suggest that risk for depression is associated with a pervasive emotional insensitivity in the face of positive and negative social feedback.

Item Type:	Article
Uncontrolled Keywords:	adolescence,biopsychosocial,depressive risk,emotion context insensitivity,partial least squares,behavioral neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2802
Faculty \ School:	Faculty of Social Sciences > School of Psychology
UEA Research Groups:	Faculty of Social Sciences > Research Groups > Cognition, Action and Perception Faculty of Social Sciences > Research Groups > Developmental Science
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	06 Jan 2021 00:58
Last Modified:	04 Jul 2025 00:00
URI:	https://ueaeprints.uea.ac.uk/id/eprint/78050
DOI:	10.1002/brb3.2005

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