Age differences in retrieval-related reinstatement reflect age-related dedifferentiation at encoding

Hill, Paul F., King, Danielle R. and Rugg, Michael D. (2021) Age differences in retrieval-related reinstatement reflect age-related dedifferentiation at encoding. Cerebral Cortex, 31 (1). 106–122. ISSN 1047-3211

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Abstract

Age-related reductions in neural selectivity have been linked to cognitive decline. We examined whether age differences in the strength of retrieval-related cortical reinstatement could be explained by analogous differences in neural selectivity at encoding, and whether reinstatement was associated with memory performance in an age-dependent or an age-independent manner. Young and older adults underwent fMRI as they encoded words paired with images of faces or scenes. During a subsequent scanned memory test participants judged whether test words were studied or unstudied and, for words judged studied, also made a source memory judgment about the associated image category. Using multi-voxel pattern similarity analyses, we identified robust evidence for reduced scene reinstatement in older relative to younger adults. This decline was however largely explained by age differences in neural differentiation at encoding; moreover, a similar relationship between neural selectivity at encoding and retrieval was evident in young participants. The results suggest that, regardless of age, the selectivity with which events are neurally processed at the time of encoding can determine the strength of retrieval-related cortical reinstatement.

Item Type: Article
Additional Information: © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
Faculty \ School: Faculty of Social Sciences > School of Psychology
Depositing User: LivePure Connector
Date Deposited: 06 Jan 2021 00:57
Last Modified: 20 Jan 2021 00:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/78049
DOI: 10.1093/cercor/bhaa210

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