Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: A systematic review and meta-analyses

Brainard, Julii, Hammer, Charlotte C., Hunter, Paul R., Katzer, Frank, Hurle, Georgina and Tyler, Kevin (2020) Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: A systematic review and meta-analyses. Parasitology. ISSN 0031-1820

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Abstract

Prior systematic review on the efficacy of halofuginone treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for treatment of calves with halofuginone. Evaluated outcomes were oocyst shedding, diarrhea, mortality and weight gain. Experiments had to describe results for same age animals in contemporary arms. Most doses were 100 to 150 mcg/kg/day. Results were subgrouped by study design, experiments with lowest risk of bias and lack of industry funding. Eighteen articles were found that described 25 experiments. Most evidence came from randomized controlled trials in Europe. Significantly lower incidence of oocyst shedding, diarrhea burden and mortality was reported when treatment started before calves were 5 days old. Most studies reported on outcomes for animals up to at least 28 days old. Publication bias was possible in all outcomes and seemed especially likely for diarrhea outcomes. Beneficial results when halofuginone treatment was initiated in calves older than 5 days were also found. Prophylactic treatment to prevent cryptosporidiosis is effective in preventing multiple negative outcomes and is beneficial to calf health and will result in a reduction of environmental contamination by Cryptosporidium oocysts.

Item Type: Article
Uncontrolled Keywords: halofuginone,bovine calves,cryptosporidiosis,diarrhea,dairy
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 09 Dec 2020 01:07
Last Modified: 20 Jan 2021 00:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/77918
DOI: 10.1017/S0031182020002267

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