Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

Akhtar, Amna, Andleeb, Anisa, Waris, Tayyba Sher, Bazzar, Masoomeh, Moradi, Ali-Reza, Awan, Nasir Raza and Yar, Muhammad (2021) Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics. Journal of Controlled Release, 330. pp. 1152-1167. ISSN 0168-3659

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Abstract

The central nervous system (CNS) encompasses the brain and spinal cord and is considered the processing center and the most vital part of human body. The central nervous system (CNS) barriers are crucial interfaces between the CNS and the periphery. Among all these biological barriers, the blood-brain barrier (BBB) strongly impede hurdle for drug transport to brain. It is a semi-permeable diffusion barrier against the noxious chemicals and harmful substances present in the blood stream and regulates the nutrients delivery to the brain for its proper functioning. Neurological diseases owing to the existence of the BBB and the blood-spinal cord barrier have been terrible and threatening challenges all over the world and can rarely be directly mediated. In fact, drug delivery to brain remained a challenge in the treatment of neurodegenerative (ND) disorders, for these different approaches have been proposed. Nano-fabricated smart drug delivery systems and implantable drug loaded biomaterials for brain repair are among some of these latest approaches. In current review, modern approaches developed to deal with the challenges associated with transporting drugs to the CNS are included. Recent studies on neural drug discovery and injectable hydrogels provide a potential new treatment option for neurological disorders. Moreover, induced pluripotent stem cells used to model ND diseases are discussed to evaluate drug efficacy. These protocols and recent developments will enable discovery of more effective drug delivery systems for brain.

Item Type: Article
Uncontrolled Keywords: blood brain barrier,brain targeted drug delivery,injectable,nanotechnology,neurodegenerative diseases,polymer implants,stem cells,pharmaceutical science ,/dk/atira/pure/subjectarea/asjc/3000/3003
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 18 Nov 2020 00:59
Last Modified: 09 Jul 2021 07:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/77727
DOI: 10.1016/j.jconrel.2020.11.021

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