Two-hit wonders: The expanding universe of multitargeting epigenetic agents

De Lera, Angel R. and Ganesan, A. ORCID: (2020) Two-hit wonders: The expanding universe of multitargeting epigenetic agents. Current Opinion in Chemical Biology, 57. pp. 135-154. ISSN 1367-5931

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Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects.

Item Type: Article
Uncontrolled Keywords: chemical probes,drug discovery,epigenetics,multitargeting agents,analytical chemistry,biochemistry ,/dk/atira/pure/subjectarea/asjc/1600/1602
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
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Depositing User: LivePure Connector
Date Deposited: 12 Nov 2020 01:08
Last Modified: 22 Oct 2022 07:16
DOI: 10.1016/j.cbpa.2020.05.009

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