A natural mutation in Pisum sativum L. (pea) alters starch assembly and improves glucose homeostasis in humans

Petropoulou, Katerina, Salt, Louise, Edwards, Cathrina, Warren, Frederick, Garcia-Perez, Isabel, Perez-Moral, Natalia, Cross, Kathryn, Kellingray, Lee, Stanley, Rachael, Koev, Todor, Khimyak, Yaroslav, Narbad, Arjan, Penney, Nicholas, Serrano-Contreras, Jose Ivan, Chambers, Edward, Alshaalan, Rasha, Khatib, Mai, Charalambides, Maria, Miguens Blanco, Jesus, Castro Seoane, Rocio, McDonald, Julie A. K., Marchesi, Julian R., Holmes, Elaine, Godsland, Ian F., Morrison, Douglas J., Preston, Tom, Domoney, Claire, Wilde, Peter and Frost, Gary (2020) A natural mutation in Pisum sativum L. (pea) alters starch assembly and improves glucose homeostasis in humans. Nature Food, 1. 693–704. ISSN 2662-1355

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Elevated postprandial glucose (PPG) is a significant driver of non-communicable 46 diseases globally. Carbohydrate-rich foods are a major determinant of PPG. Currently there is 47 a limited understanding of how starch structure within a food-matrix interacts with the gut 48 luminal environment to control PPG. We use pea seeds (Pisum sativum), as a model-food, to 49 explore the contribution of starch structure, food-matrix and intestinal environment on PPG. 50 Using stable isotope [13C] labelled seeds, coupled with synchronous gastric, duodenal and 51 plasma sampling in vivo, we demonstrate that maintenance of cell structure and changes in 52 starch morphology are closely related to lower glucose availability in the small intestine, 53 resulting in acutely lower PPG and promoting changes in the gut bacterial composition 54 associated with long term metabolic health improvements. This work offers huge potential to 55 improve the design of food products targeted at moderating PPG and therefore lowering the 56 risk of non-communicable diseases

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 11 Nov 2020 01:15
Last Modified: 11 May 2021 00:11
URI: https://ueaeprints.uea.ac.uk/id/eprint/77625
DOI: 10.1038/s43016-020-00159-8

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