Increased Substitution Rates Surrounding Low-Complexity Regions within Primate Proteins

Lenz, Carolyn, Haerty, Wilfried ORCID: and Golding, G. Brian (2014) Increased Substitution Rates Surrounding Low-Complexity Regions within Primate Proteins. Genome Biology and Evolution, 6 (3). pp. 655-665. ISSN 1759-6653

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Previous studies have found that DNA-flanking low-complexity regions (LCRs) have an increased substitution rate. Here, the substitution rate was confirmed to increase in the vicinity of LCRs in several primate species, including humans. This effect was also found among human sequences from the 1000 Genomes Project. A strong correlation was found between average substitution rate per site and distance from the LCR, as well as the proportion of genes with gaps in the alignment at each site and distance from the LCR. Along with substitution rates, dN/dS ratios were also determined for each site, and the proportion of sites undergoing negative selection was found to have a negative relationship with distance from the LCR.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
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Depositing User: LivePure Connector
Date Deposited: 07 Nov 2020 01:10
Last Modified: 21 Apr 2023 00:50
DOI: 10.1093/gbe/evu042

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