The tomato receptor CuRe1 senses a cell wall protein to identify Cuscuta as a pathogen

Hegenauer, Volker, Slaby, Peter, Körner, Max, Bruckmüller, Julien Alexander, Burggraf, Ronja, Albert, Isabell, Kaiser, Bettina, Löffelhardt, Birgit, Droste-Borel, Irina, Sklenar, Jan, Menke, Frank L.H. ORCID:, Maček, Boris, Ranjan, Aashish, Sinha, Neelima, Nürnberger, Thorsten, Felix, Georg, Krause, Kirsten, Stahl, Mark and Albert, Markus (2020) The tomato receptor CuRe1 senses a cell wall protein to identify Cuscuta as a pathogen. Nature Communications, 11 (1). ISSN 2041-1723

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Parasitic plants of the genus Cuscuta penetrate shoots of host plants with haustoria and build a connection to the host vasculature to exhaust water, solutes and carbohydrates. Such infections usually stay unrecognized by the host and lead to harmful host plant damage. Here, we show a molecular mechanism of how plants can sense parasitic Cuscuta. We isolated an 11 kDa protein of the parasite cell wall and identified it as a glycine-rich protein (GRP). This GRP, as well as its minimal peptide epitope Crip21, serve as a pathogen-associated molecular pattern and specifically bind and activate a membrane-bound immune receptor of tomato, the Cuscuta Receptor 1 (CuRe1), leading to defense responses in resistant hosts. These findings provide the initial steps to understand the resistance mechanisms against parasitic plants and further offer great potential for protecting crops by engineering resistance against parasitic plants.

Item Type: Article
Uncontrolled Keywords: chemistry(all),biochemistry, genetics and molecular biology(all),physics and astronomy(all) ,/dk/atira/pure/subjectarea/asjc/1600
Faculty \ School: Faculty of Science > The Sainsbury Laboratory
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Depositing User: LivePure Connector
Date Deposited: 31 Oct 2020 01:08
Last Modified: 22 Oct 2022 07:23
DOI: 10.1038/s41467-020-19147-4


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