Use of tissue plasminogen activator to treat intracardiac thrombosis in extremely low-birth-weight infants

Bose, Jayanti and Clarke, Paul (2011) Use of tissue plasminogen activator to treat intracardiac thrombosis in extremely low-birth-weight infants. Pediatric Critical Care Medicine, 12 (6). e407-e409. ISSN 1529-7535

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Abstract

Objective: Intracardiac thrombosis is a life-threatening complication of extreme prematurity. We describe the use of tissue plasminogen activator to treat intracardiac thrombosis in extremely low-birth-weight preterm infants. Design: Case series, literature review, and practice guideline for recombinant tissue plasminogen activator treatment of intracardiac thrombosis in extremely low-birth-weight preterm infants. Setting: Neonatal intensive care. Patients: Four extremely low-birth-weight preterm infants coincidentally diagnosed with intracardiac thrombosis during neonatal intensive care. Interventions: Recombinant tissue plasminogen activator in a starting dose of 20 μg/kg/hr, increasing to 200-400 μg/kg/hr, infused for 2-6 days. Measurements and Main Results: Thrombolytic therapy with recombinant tissue plasminogen activator helped achieve rapid clot resolution in all infants and none had any major hemorrhagic complication associated with treatment. Conclusions: Tissue plasminogen activator may safely be used to treat intracardiac thrombosis in extremely low-birth-weight preterm infants. Close monitoring of therapy is imperative. Further data are required to confirm the safety of tissue plasminogen activator in preterm infants.

Item Type: Article
Uncontrolled Keywords: antithrombotic,clot,complications,fibrinolytic,preterm,thrombolytics,thrombus,pediatrics, perinatology, and child health,critical care and intensive care medicine ,/dk/atira/pure/subjectarea/asjc/2700/2735
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Depositing User: LivePure Connector
Date Deposited: 16 Oct 2020 23:57
Last Modified: 16 Oct 2020 23:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/77299
DOI: 10.1097/PCC.0b013e3181fe449f

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