Platelets for neonatal transfusion - Study 2:A randomised controlled trial to compare two different platelet count thresholds for prophylactic platelet transfusion to preterm neonates

Curley, Anna, Venkatesh, Vidheya, Stanworth, Simon, Clarke, Paul ORCID: https://orcid.org/0000-0001-6203-7632, Watts, Timothy, New, Helen, Willoughby, Karen, Khan, Rizwan, Muthukumar, Priya and Deary, Alison (2014) Platelets for neonatal transfusion - Study 2:A randomised controlled trial to compare two different platelet count thresholds for prophylactic platelet transfusion to preterm neonates. Neonatology, 106 (2). pp. 102-106. ISSN 1661-7800

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Abstract

Introduction: Neonatal thrombocytopenia is a common and important clinical problem in preterm neonates. A trial assessing clinically relevant outcomes in relation to the different platelet count thresholds used to trigger transfusion has never been undertaken in preterm neonates with severe thrombocytopenia. Objectives: Platelets for Neonatal Transfusion - Study 2 (PlaNeT-2) aims to assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in current standard practice in reducing the proportion of patients who have a major bleed or die up to study day 28. Methods: PlaNeT-2 is a two-stage, randomised, parallel-group, superiority trial. PlaNet-2 compares clinical outcomes in preterm neonates (<34 weeks' gestation at birth) randomised to receive prophylactic platelet transfusions to maintain platelet counts at or above either 25 × 109/l or 50 × 10 9/l. The primary outcome measure is the proportion of patients who either die or experience a major bleed up to and including study day 28. A total of 660 infants will be randomised. Results and Conclusions: This trial will help define optimal platelet transfusion support for severely thrombocytopenic preterm neonates by evaluating the risks and benefits of two different prophylactic neonatal platelet transfusion thresholds.

Item Type: Article
Uncontrolled Keywords: newborn,platelets,thrombocytopenia,transfusion,pediatrics, perinatology, and child health,developmental biology ,/dk/atira/pure/subjectarea/asjc/2700/2735
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Depositing User: LivePure Connector
Date Deposited: 16 Oct 2020 23:57
Last Modified: 11 Aug 2022 19:45
URI: https://ueaeprints.uea.ac.uk/id/eprint/77283
DOI: 10.1159/000358481

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