Anti-inflammatories in Alzheimer’s disease – potential therapy or spurious correlate?

Rivers-Auty, Jack, Mather, Alison, Peters, Ruth, Lawrence, Catherine B. and Brough, David (2020) Anti-inflammatories in Alzheimer’s disease – potential therapy or spurious correlate? Brain Communications, 2 (2). ISSN 2632-1297

[thumbnail of Published_Version]
PDF (Published_Version) - Published Version
Available under License Creative Commons Attribution.

Download (557kB) | Preview


Epidemiological evidence suggests non-steroidal anti-inflammatories (NSAIDs) reduce the risk of Alzheimer’s disease. However, clinical trials have found no evidence of NSAID efficacy. This incongruence may be due to the wrong NSAIDs being tested in robust clinical trials or the epidemiological findings being caused by confounding factors. Therefore, this study used logistic regression and the innovative approach of negative binomial generalised linear mixed modelling to investigate both prevalence and cognitive decline, respectively, in the Alzheimer’s Disease NeuroImaging dataset for each commonly used NSAID and paracetamol. Use of most NSAIDs were associated with reduced Alzheimer’s disease prevalence yet no effect on cognitive decline was observed. Paracetamol had a similar effect on prevalence to these NSAIDs suggesting this association is independent of the anti-inflammatory effects and that previous results may be due to spurious associations. Interestingly, diclofenac use was significantly associated with both reduce incidence and slower cognitive decline warranting further research into the potential therapeutic effects of diclofenac in Alzheimer’s disease.

Item Type: Article
Uncontrolled Keywords: alzheimer's disease,anti-inflammatory,inflammation,nsaid,progression,psychiatry and mental health,biological psychiatry,cellular and molecular neuroscience,neurology ,/dk/atira/pure/subjectarea/asjc/2700/2738
Faculty \ School:
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 14 Oct 2020 23:59
Last Modified: 06 Jun 2024 15:13
DOI: 10.1093/braincomms/fcaa109


Downloads per month over past year

Actions (login required)

View Item View Item