Chemoenzymatic synthesis of fluorinated cellodextrins identifies a new allomorph for cellulose‐like materials

de Andrade, Peterson, Muñoz-García, Juan C., Pergolizzi, Giulia, Gabrielli, Valeria, Nepogodiev, Sergey, Iuga, Dinu, Fabian, Laszlo, Nigmatullin, Rinat, Johns, Marcus A., Harniman, Robert, Eichhorn, Stephen J., Angulo Alvarez, Jesus ORCID:, Khimyak, Yaroslav ORCID: and Field, Robert A. (2021) Chemoenzymatic synthesis of fluorinated cellodextrins identifies a new allomorph for cellulose‐like materials. Chemistry - A European Journal, 27 (4). pp. 1374-1382. ISSN 0947-6539

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Understanding the fine details of the self-assembly of building blocks into complex hierarchical structures represents a major challenge en route to the design and preparation of soft-matter materials with specific properties. Enzymatically synthesised cellodextrins are known to have limited water solubility beyond DP9, a point at which they self-assemble into particles resembling the antiparallel cellulose II crystalline packing. We have prepared and characterised a series of site-selectively fluorinated cellodextrins with different degrees of fluorination and substitution patterns by chemoenzymatic synthesis. Bearing in mind the potential disruption of the hydrogen-bond network of cellulose II, we have prepared and characterised a multiply 6-fluorinated cellodextrin. In addition, a series of single site-selectively fluorinated cellodextrins was synthesised to assess the structural impact upon the addition of one fluorine atom per chain. The structural characterisation of these materials at different length scales, combining advanced NMR spectroscopy and microscopy methods, showed that a 6-fluorinated donor substrate yielded multiply 6-fluorinated cellodextrin chains that assembled into particles presenting morphological and crystallinity features, and intermolecular interactions, that are unprecedented for cellulose-like materials.

Item Type: Article
Uncontrolled Keywords: allomorphs,cellodextrins,chemoenzymatic synthesis,fluorine,soft-matter materials,catalysis,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1500/1503
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
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Depositing User: LivePure Connector
Date Deposited: 30 Sep 2020 23:57
Last Modified: 20 Apr 2023 18:33
DOI: 10.1002/chem.202003604


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