Lower dietary and circulating vitamin C in middle and older aged men and women are associated with lower estimated skeletal muscle mass

Lewis, Lucy, Hayhoe, Richard, Mulligan, Angela, Luben, Robert, Khaw, K. T. and Welch, Ailsa (2020) Lower dietary and circulating vitamin C in middle and older aged men and women are associated with lower estimated skeletal muscle mass. Journal of Nutrition. ISSN 0022-3166

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Abstract

Background: Age-related loss of skeletal muscle mass contributes to poor outcomes including sarcopenia, physical disability, frailty, type-2 diabetes, and mortality. Vitamin C has physiological relevance to skeletal muscle and may protect it during ageing, but few studies have investigated its importance in older populations.Objective: Investigate cross-sectional associations between dietary and plasma vitamin C with proxy measures of skeletal muscle mass in a large cohort of middle and older-aged individuals. Methods: We analysed data from >13,000 men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort, aged 42-82 years. Fat free mass (FFM), as a proxy for skeletal muscle mass, was estimated using bioelectrical impedance analysis and expressed as a percentage of total mass (FFM%) or divided by BMI (FFMBMI). Dietary vitamin C intakes were calculated from 7-day food diary data, and plasma vitamin C was measured in peripheral blood.Multivariable regression models, including relevant lifestyle, dietary and biological covariates, were used to determine associations between FFM measures and quintiles of dietary vitamin C or insufficient versus sufficient plasma vitamin C (<50μmol/L and ≥50μmol/L). Results: Positive trends were found across quintiles of dietary vitamin C and FFM measures for both sexes, with interquintile differences in FFM% and FFMBMI of 1.0% and 2.3% for men and 1.9 and 2.9% for women (all p<0.001). Similarly, FFM% and FFMBMI measures were higher in participants with sufficient versus insufficient plasma vitamin C: 1.6% and 2.0% in men, and 3.4% and 3.9% in women (all p<0.001). Associations were also evident in analyses stratified into <65y and ≥65y age groups.Conclusions: Our findings of positive associations, between both dietary and circulating vitamin C and measures of skeletal muscle mass in middle and older aged men and women, suggests that dietary vitamin C intake may be useful for reducing age-related muscle loss.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 07 Sep 2020 23:55
Last Modified: 24 Sep 2020 00:02
URI: https://ueaeprints.uea.ac.uk/id/eprint/76789
DOI: 10.1093/jn/nxaa221

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