Test-retest reliability of spatial navigation in at-risk Alzheimer’s disease

Coughlan, Gillian, Puthusseryppady, Vaisakh, Lowry, Ellen, Minihane, Anne-Marie, Spiers, Hugo J., Gillings, Rachel and Hornberger, Michael (2020) Test-retest reliability of spatial navigation in at-risk Alzheimer’s disease. PLoS One. ISSN 1932-6203 (In Press)

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Abstract

The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated intraclass correlation coefficients (ICC) for all task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test–retest reliability (ICC=.72), followed by the SHQ distance travelled parameter (ICC=.50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in the high-risk (F=5.01, P=0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Social Sciences > School of Psychology
Depositing User: LivePure Connector
Date Deposited: 02 Sep 2020 23:53
Last Modified: 21 Sep 2020 00:03
URI: https://ueaeprints.uea.ac.uk/id/eprint/76726
DOI:

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