Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease

Coughlan, Gillian, Puthusseryppady, Vaisakh, Lowry, Ellen, Gillings, Rachel, Spiers, Hugo J., Minihane, Anne-Marie and Hornberger, Michael (2020) Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease. PLoS One, 15 (9). ISSN 1932-6203

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Abstract

The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer‘s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test–retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.

Item Type:	Article
Additional Information:	Data Availability: All data are available from the Open Science Framework. All data: (https://osf.io/x2rjz). Shq_subgroup: (https://osf.io/6adqk).
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Social Sciences > School of Psychology
UEA Research Groups:	Faculty of Social Sciences > Research Groups > Cognition, Action and Perception Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	02 Sep 2020 23:53
Last Modified:	29 Jun 2025 00:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/76726
DOI:	10.1371/journal.pone.0239077

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