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Coughlan, Gillian, Puthusseryppady, Vaisakh, Lowry, Ellen, Gillings, Rachel, Spiers, Hugo J., Minihane, Anne-Marie 
ORCID: https://orcid.org/0000-0001-9042-4226 and Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788
(2020)
Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease.
PLoS One, 15 (9).
ISSN 1932-6203
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Abstract
The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer‘s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test–retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability: All data are available from the Open Science Framework. All data: (https://osf.io/x2rjz). Shq_subgroup: (https://osf.io/6adqk). |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Social Sciences > School of Psychology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Sep 2020 23:53 |
| Last Modified: | 22 Oct 2022 06:43 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/76726 |
| DOI: | 10.1371/journal.pone.0239077 |
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