Zika virus causes persistent infection in porcine conceptuses and may impair health in offspring

Darbellay, Joseph, Cox, Brian, Lai, Kenneth, Delgado-Ortega, Mario, Wheler, Colette, Wilson, Donald, Walker, Stewart, Starrak, Gregory, Hockley, Duncan, Huang, Yanyun, Mutwiri, George, Potter, Andrew, Gilmour, Matthew, Safronetz, David, Gerdts, Volker and Karniychuk, Uladzimir (2017) Zika virus causes persistent infection in porcine conceptuses and may impair health in offspring. EBioMedicine, 25. pp. 73-86. ISSN 2352-3964

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Abstract

Outcomes of Zika virus (ZIKV) infection in pregnant women vary from the birth of asymptomatic offspring to abnormal development and severe brain lesions in fetuses and infants. There are concerns that offspring affected in utero and born without apparent symptoms may develop mental illnesses. Therefore, animal models are important to test interventions against in utero infection and health sequelae in symptomatic and likely more widespread asymptomatic offspring. To partially reproduce in utero infection in humans, we directly inoculated selected porcine conceptuses with ZIKV. Inoculation resulted in rapid trans-fetal infections, persistent infection in conceptuses, molecular pathology in fetal brains, fetal antibody and type I interferon responses. Offspring infected in utero showed ZIKV in their fetal membranes collected after birth. Some in utero affected piglets were small, depressed, had undersized brains, and showed seizures. Some piglets showed potentially increased activity. Our data suggest that porcine model of persistent in utero ZIKV infection has a strong potential for translational research and can be used to test therapeutic interventions in vivo.

Item Type: Article
Additional Information: Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved. Corrigendum to "Zika Virus Causes Persistent Infection in Porcine Conceptuses and May Impair Health in Offspring". EBioMedicine. 2017 Nov;25:187. doi: 10.1016/j.ebiom.2017.10.021
Uncontrolled Keywords: animals,pathology,transmission,female,virology,humans,pregnancy,pathology,virology,pathogenicity,pathology
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 28 Aug 2020 00:04
Last Modified: 09 Jul 2021 06:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/76683
DOI: 10.1016/j.ebiom.2017.09.021

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