Intra-articular pressure changes in rheumatoid and normal peripheral joints

Gaffney, K ORCID:, Williams, R B, Jolliffe, V A and Blake, D R (1995) Intra-articular pressure changes in rheumatoid and normal peripheral joints. Annals of the Rheumatic Diseases, 54 (8). pp. 670-673. ISSN 0003-4967

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OBJECTIVE: To investigate the intraarticular pressure (IAP) dynamics of a spectrum of joints in rheumatoid and normal subjects in order to determine whether a reperfusion event is likely to occur at these sites. METHODS: IAP was measured in the metacarpophalangeal (MCP) (n = 8), wrist (n = 8), ankle (n = 4), and elbow joints (n = 4) of rheumatoid subjects, in addition to the MCP (n = 8), wrist (n = 6), and ankle joints (n = 1) of normal healthy controls, using the hand held portable 295-1 Intra-Compartmental Pressure Monitor System (Stryker, UK). RESULTS: Resting IAP was positive in all rheumatoid joints, and subatmospheric or weakly atmospheric in normal subjects (p < 0.01). Exercise produced an increase in IAP in rheumatoid subjects only (p < 0.01). The addition of saline to normal joints mimicked the IAP changes seen in the rheumatoid group. CONCLUSION: These observations suggest that increased resting IAP is a marker for chronic joint inflammation. The IAP increase seen in the rheumatoid group during exercise supports the concept of hypoxic reperfusion mediated joint injury.

Item Type: Article
Uncontrolled Keywords: adult,aged,physiopathology,physiopathology,physiopathology,physiology,female,humans,physiopathology,male,physiopathology,middle aged,pressure,physiopathology,physiopathology
Depositing User: LivePure Connector
Date Deposited: 26 Aug 2020 00:02
Last Modified: 22 Oct 2022 06:40
DOI: 10.1136/ard.54.8.670

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