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Gaffney, K 
ORCID: https://orcid.org/0000-0002-7863-9176, Williams, R B, Jolliffe, V A and Blake, D R
(1995)
Intra-articular pressure changes in rheumatoid and normal peripheral joints.
Annals of the Rheumatic Diseases, 54 (8).
pp. 670-673.
ISSN 0003-4967
Abstract
OBJECTIVE: To investigate the intraarticular pressure (IAP) dynamics of a spectrum of joints in rheumatoid and normal subjects in order to determine whether a reperfusion event is likely to occur at these sites. METHODS: IAP was measured in the metacarpophalangeal (MCP) (n = 8), wrist (n = 8), ankle (n = 4), and elbow joints (n = 4) of rheumatoid subjects, in addition to the MCP (n = 8), wrist (n = 6), and ankle joints (n = 1) of normal healthy controls, using the hand held portable 295-1 Intra-Compartmental Pressure Monitor System (Stryker, UK). RESULTS: Resting IAP was positive in all rheumatoid joints, and subatmospheric or weakly atmospheric in normal subjects (p < 0.01). Exercise produced an increase in IAP in rheumatoid subjects only (p < 0.01). The addition of saline to normal joints mimicked the IAP changes seen in the rheumatoid group. CONCLUSION: These observations suggest that increased resting IAP is a marker for chronic joint inflammation. The IAP increase seen in the rheumatoid group during exercise supports the concept of hypoxic reperfusion mediated joint injury.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adult,aged,physiopathology,physiopathology,physiopathology,physiology,female,humans,physiopathology,male,physiopathology,middle aged,pressure,physiopathology,physiopathology |
| Depositing User: | LivePure Connector |
| Date Deposited: | 26 Aug 2020 00:02 |
| Last Modified: | 22 Oct 2022 06:40 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/76647 |
| DOI: | 10.1136/ard.54.8.670 |
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