Quantification of rheumatoid synovitis by magnetic resonance imaging

Gaffney, Karl ORCID: https://orcid.org/0000-0002-7863-9176, Cookson, John, Blake, David, Coumbe, Adam and Blades, Selina (1995) Quantification of rheumatoid synovitis by magnetic resonance imaging. Arthritis and Rheumatism, 38 (11). pp. 1610-1617. ISSN 0004-3591

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OBJECTIVE: To develop a method for quantifying acute synovial inflammation in rheumatoid arthritis (RA), utilizing magnetic resonance imaging (MRI). METHODS: Gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI was performed in 21 patients with knee synovitis. Changes in synovial membrane signal intensity were identified and quantified by line profile analysis. Multiple synovial biopsies were obtained by a blind biopsy technique, and standard clinical and laboratory measurements of disease activity were recorded. RESULTS: The rate of synovial membrane enhancement correlated with histologic features of acute inflammation (r = 0.63, P < 0.01), but not with clinical or laboratory assessments. CONCLUSION: Dynamic MRI is a valuable technique for assessing acute synovial inflammation in RA.

Item Type: Article
Uncontrolled Keywords: adult,aged,complications,contrast media,female,gadolinium dtpa,humans,magnetic resonance imaging,male,middle aged,organometallic compounds,analogs & derivatives,complications
Depositing User: LivePure Connector
Date Deposited: 26 Aug 2020 00:02
Last Modified: 22 Oct 2022 06:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/76646
DOI: 10.1002/art.1780381113

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