Quantification of rheumatoid synovitis by magnetic resonance imaging

Gaffney, Karl, Cookson, John, Blake, David, Coumbe, Adam and Blades, Selina (1995) Quantification of rheumatoid synovitis by magnetic resonance imaging. Arthritis and Rheumatism, 38 (11). pp. 1610-1617. ISSN 0004-3591

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Abstract

OBJECTIVE: To develop a method for quantifying acute synovial inflammation in rheumatoid arthritis (RA), utilizing magnetic resonance imaging (MRI). METHODS: Gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI was performed in 21 patients with knee synovitis. Changes in synovial membrane signal intensity were identified and quantified by line profile analysis. Multiple synovial biopsies were obtained by a blind biopsy technique, and standard clinical and laboratory measurements of disease activity were recorded. RESULTS: The rate of synovial membrane enhancement correlated with histologic features of acute inflammation (r = 0.63, P < 0.01), but not with clinical or laboratory assessments. CONCLUSION: Dynamic MRI is a valuable technique for assessing acute synovial inflammation in RA.

Item Type:	Article
Uncontrolled Keywords:	adult,aged,complications,contrast media,female,gadolinium dtpa,humans,magnetic resonance imaging,male,middle aged,organometallic compounds,analogs & derivatives,complications
Depositing User:	LivePure Connector
Date Deposited:	26 Aug 2020 00:02
Last Modified:	28 Mar 2025 10:10
URI:	https://ueaeprints.uea.ac.uk/id/eprint/76646
DOI:	10.1002/art.1780381113

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