Effectively Measuring Exercise-Related Variations in T1ρ and T2 Relaxation Times of Healthy Articular Cartilage

Kessler, Dimitri A., MacKay, James W., McDonald, Scott, McDonnell, Stephen, Grainger, Andrew J., Roberts, Alexandra R., Janiczek, Robert L., Graves, Martin J., Kaggie, Joshua D. and Gilbert, Fiona J. (2020) Effectively Measuring Exercise-Related Variations in T1ρ and T2 Relaxation Times of Healthy Articular Cartilage. Journal of Magnetic Resonance Imaging. ISSN 1053-1807

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Abstract

Background: Determining the compositional response of articular cartilage to dynamic joint-loading using MRI may be a more sensitive assessment of cartilage status than conventional static imaging. However, distinguishing the effects of joint-loading vs. inherent measurement variability remains difficult, as the repeatability of these quantitative methods is often not assessed or reported. Purpose: To assess exercise-induced changes in femoral, tibial, and patellar articular cartilage composition and compare these against measurement repeatability. Study Type: Prospective observational study. Population: Phantom and 19 healthy participants. Field Strength/Sequence: 3T; 3D fat-saturated spoiled gradient recalled-echo; T1ρ- and T2-prepared pseudosteady-state 3D fast spin echo. Assessment: The intrasessional repeatability of T1ρ and T2 relaxation mapping, with and without knee repositioning between two successive measurements, was determined in 10 knees. T1ρ and T2 relaxation mapping of nine knees was performed before and at multiple timepoints after a 5-minute repeated, joint-loading stepping activity. 3D surface models were created from patellar, femoral, and tibial articular cartilage. Statistical Tests: Repeatability was assessed using root-mean-squared-CV (RMS-CV). Using Bland–Altman analysis, thresholds defined as the smallest detectable difference (SDD) were determined from the repeatability data with knee repositioning. Results: Without knee repositioning, both surface-averaged T1ρ and T2 were very repeatable on all cartilage surfaces, with RMS-CV <1.1%. Repositioning of the knee had the greatest effect on T1ρ of patellar cartilage with the surface-averaged RMS-CV = 4.8%. While T1ρ showed the greatest response to exercise at the patellofemoral cartilage region, the largest changes in T2 were determined in the lateral femorotibial region. Following thresholding, significant (>SDD) average exercise-induced in T1ρ and T2 of femoral (–8.0% and –5.3%), lateral tibial (–6.9% and –5.9%), medial tibial (+5.8% and +2.9%), and patellar (–7.9% and +2.8%) cartilage were observed. Data Conclusion: Joint-loading with a stepping activity resulted in T1ρ and T2 changes above background measurement error. Evidence Level: 2. Technical Efficacy Stage: 1.

Item Type: Article
Uncontrolled Keywords: articular cartilage,exercise,mri,quantitative imaging,relaxation time,repeatability,radiology nuclear medicine and imaging ,/dk/atira/pure/subjectarea/asjc/2700/2741
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 12 Aug 2020 23:54
Last Modified: 18 Sep 2020 23:53
URI: https://ueaeprints.uea.ac.uk/id/eprint/76421
DOI: 10.1002/jmri.27278

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