Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus
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ToolsGoodman, Timothy, Nayar, Stuart G., Clare, Shaun, Mikolajczak, Marta, Rice, Ritva, Mansour, Suzanne, Bellusci, Saverio and Hajihosseini, Mohammad K. (2020) Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus. Development, 147 (13). ISSN 0950-1991
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Abstract
New neurons are generated in the postnatal rodent hypothalamus, with a subset of tanycytes in the third ventricular (3V) wall serving as neural stem/progenitor cells. However, the precise stem cell niche organization, the intermediate steps and the endogenous regulators of postnatal hypothalamic neurogenesis remain elusive. Quantitative lineage-tracing in vivo revealed that conditional deletion of fibroblast growth factor 10 (Fgf10) from Fgf10-expressing β-tanycytes at postnatal days (P)4-5 results in the generation of significantly more parenchymal cells by P28, composed mostly of ventromedial and dorsomedial neurons and some glial cells, which persist into adulthood. A closer scrutiny in vivo and ex vivo revealed that the 3V wall is not static and is amenable to cell movements. Furthermore, normally β-tanycytes give rise to parenchymal cells via an intermediate population of α-tanycytes with transient amplifying cell characteristics. Loss of Fgf10 temporarily attenuates the amplification of β-tanycytes but also appears to delay the exit of their α-tanycyte descendants from the germinal 3V wall. Our findings suggest that transience of cells through the α-tanycyte domain is a key feature, and Fgf10 is a negative regulator of postnatal hypothalamic neurogenesis.
| Item Type: | Article |
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| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 22 Jul 2020 02:46 |
| Last Modified: | 22 Jul 2020 02:46 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/76216 |
| DOI: | 10.1242/dev.180950 |
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