Antibacterial diterpenes from Plectranthus ernstii

Stavri, Michael, Paton, Alan, Skelton, Brian W. and Gibbons, Simon (2009) Antibacterial diterpenes from Plectranthus ernstii. Journal of Natural Products, 72 (6). pp. 1191-1194. ISSN 0163-3864

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Three new diterpenoids including two pimaranes (1 and 2) and a labdane (3) were isolated from the whole herb of Plectranthus ernstii. The structures of these compounds were determined as rel-15(?),16-epoxy-7?-hydroxypimar-8,14-ene (1) and rel-15(?),16-epoxy-7-oxopimar-8,14-ene (2), and compound 3 was elucidated as 1R,11S-dihydroxy-8R,13R-epoxylabd-14-ene on the basis of single-crystal X-ray structural analysis. Compound 1 exhibited moderate antistaphylococcal activity against a range of multidrug-resistant (MDR) and methicillin-resistant (MRSA) strains of Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 32 ?g/mL. All three diterpenes exhibited antimycobacterial activity against three strains of rapidly growing mycobacteria with MIC values ranging from 8 to 128 ?g/mL.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 16 Jul 2020 23:47
Last Modified: 22 Oct 2022 06:29
DOI: 10.1021/np800581s

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