Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense

Wang, Wei, Zeng, Yi Han, Osman, Khadijo, Shinde, Kamlesh, Rahman, Mukhlesur, Gibbons, Simon and Mu, Qing (2010) Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. Journal of Natural Products, 73 (11). pp. 1815-1820. ISSN 0163-3864

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Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 ?g/mL (8.4 ?M) and 4 ?g/mL (16.8 ?M), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 ?g/mL (100 ?M).

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 15 Jul 2020 23:39
Last Modified: 22 Oct 2022 06:29
DOI: 10.1021/np1004483

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