Prenylated benzophenone peroxide derivatives from Hypericum sampsonii

Xiao, Zhi Yong, Zeng, Yi Han, Mu, Qing, Shiu, Winnie Ka Po and Gibbons, Simon (2010) Prenylated benzophenone peroxide derivatives from Hypericum sampsonii. Chemistry and Biodiversity, 7 (4). pp. 953-958. ISSN 1612-1872

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Abstract

Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B (1 and 2, resp.), together with a known compound, plukenetione C (3), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii, and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5-dioxatetracyclo[9.3.1.19,13.0 1,7]hexadecane-12,14,15-trione. In the biological test, peroxysampsone A (1) showed comparable activity with norfloxacin against a NorA over-expressing multidrug-resistant (MDR) strain of Staphylococcus aureus SA-1199B.

Item Type: Article
Uncontrolled Keywords: bioengineering,biochemistry,chemistry(all),molecular medicine,molecular biology ,/dk/atira/pure/subjectarea/asjc/1500/1502
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 15 Jul 2020 23:39
Last Modified: 15 Jul 2020 23:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/76131
DOI: 10.1002/cbdv.200900247

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