Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia

Falodun, A., Sheng-Xiang, Qiu, Parkinson, G. and Gibbons, S. (2012) Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia. Pharmaceutical Chemistry Journal, 45 (10). pp. 636-639. ISSN 0091-150X

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Abstract

Jatropha gossypifolia root bark is used in ethnomedicine for the treatment of various diseases and infections. We have studied the phytochemistry and evaluated the anticancer activity of J. gossypifolia root extract. Phytochemical investigation of the root of J. gossypifolia resulted in the isolation and characterization of one new diterpenoid along with four well-known compounds. The new compound was established by 1D and 2D NMR spectra and x-ray analysis, while spectral ( 1H, 13C NMR, and ESI-MS) characteristics of the known compounds were compared with reported data. The new compound showed potent proliferation inhibitory activity against A-549 human cancer cell line.

Item Type: Article
Uncontrolled Keywords: anticancer activity,cytotoxicity,jatropha gossypifolia,lathyrane diterpenes,root extract,pharmacology,drug discovery ,/dk/atira/pure/subjectarea/asjc/3000/3004
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 15 Jul 2020 23:39
Last Modified: 15 Jul 2020 23:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/76106
DOI: 10.1007/s11094-012-0693-4

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