Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum

Taglialatela-Scafati, Orazio, Pollastro, Federica, Chianese, Giuseppina, Minassi, Alberto, Gibbons, Simon, Arunotayanun, Warunya, Mabebie, Blessing, Ballero, Mauro and Appendino, Giovanni (2013) Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum. Journal of Natural Products, 76 (3). pp. 346-353. ISSN 0163-3864

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During a large-scale isolation campaign for the heterodimeric phloroglucinyl pyrone arzanol (1a) from Helichrysum italicum subsp. microphyllum, several new phenolics as well as an unusual class of lipids named santinols (5a-c, 6-8) have been characterized. Santinols are angeloylated glycerides characterized by the presence of branched acyl- or keto-acyl chains and represent a hitherto unreported class of plant lipids. The antibacterial activity of arzanol and of a selection of Helichrysum phenolics that includes coumarates, benzofurans, pyrones, and heterodimeric phloroglucinols was evaluated, showing that only the heterodimers showed potent antibacterial action against multidrug-resistant Staphylococcus aureus isolates. These observations validate the topical use of Helichrysum extracts to prevent wound infections, a practice firmly established in the traditional medicine of the Mediterranean area.

Item Type: Article
Uncontrolled Keywords: analytical chemistry,molecular medicine,pharmacology,pharmaceutical science,drug discovery,complementary and alternative medicine,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1602
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 15 Jul 2020 23:38
Last Modified: 22 Oct 2022 06:29
DOI: 10.1021/np3007149

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