Bacterial resistance modifying tetrasaccharide agents from Ipomoea murucoides

Chérigo, Lilia, Pereda-Miranda, Rogelio and Gibbons, Simon (2009) Bacterial resistance modifying tetrasaccharide agents from Ipomoea murucoides. Phytochemistry, 70 (2). pp. 222-227. ISSN 0031-9422

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As part of an ongoing project to identify oligosaccharides which modulate bacterial multidrug resistance, the CHCl3-soluble extract from flowers of a Mexican arborescent morning glory, Ipomoea murucoides, through preparative-scale recycling HPLC, yielded five lipophilic tetrasaccharide inhibitors of Staphylococcus aureus multidrug efflux pumps, murucoidins XII–XVI (1–5). The macrocyclic lactone-type structures for these linear hetero-tetraglycoside derivatives of jalapinolic acid were established by spectroscopic methods. These compounds were tested for in vitro antibacterial and resistance modifying activity against strains of Staphylococcus aureus possessing multidrug resistance efflux mechanisms. Only murucoidin XIV (3) displayed antimicrobial activity against SA-1199B (MIC 32 μg/ml), a norfloxacin-resistant strain that over-expresses the NorA MDR efflux pump. The four microbiologically inactive (MIC > 512 μg/ml) tetrasaccharides increased norfloxacin susceptibility of this strain by 4-fold (8 μg/ml from 32 μg/ml) at concentrations of 25 μg/ml, while murucoidin XIV (3) exerted the same potentiation effect at a concentration of 5 μg/ml.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 15 Jul 2020 23:38
Last Modified: 22 Oct 2022 06:29
DOI: 10.1016/j.phytochem.2008.12.005

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