Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production

Schiavone, Brigida Immacolata Pia, Rosato, Antonio, Marilena, Muraglia, Gibbons, Simon, Bombardelli, Ezio, Verotta, Luisella, Franchini, Carlo and Corbo, Filomena (2013) Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. Journal of Natural Products, 76 (9). pp. 1819-1823. ISSN 0163-3864

Full text not available from this repository. (Request a copy)

Abstract

Bacterial biofilms are organized communities of microorganisms, embedded in a self-produced matrix, growing on a biotic surface and resistant to many antimicrobial agents when associated with a medical device. These biofilms require the development of new strategies for the prevention and treatment of infectious disease, including the potential use of natural products. One interesting natural product example is Hypericum, a plant genus that contains species known to have antimicrobial properties. The major constituent of Hypericum perforatum is an unstable compound named hyperforin (1); for this reason it was not believed to play a significant role in the pharmacological effects. In this investigation a hydrogenated hyperforin analogue (2) was tested on several ATCC and clinical isolate strains, in their planktonic and biofilm form (Staphylococcus aureus, MRSA, and Enterococcus faecalis). Compound 2 was effective against planktonic and biofilm cultures, probably due to higher stability, showing the percentage of cells killed in the range from 452 2013 The American Chemical Society and American Society of Pharmacognosy.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 14 Jul 2020 23:51
Last Modified: 14 Jul 2020 23:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/76065
DOI: 10.1021/np400394c

Actions (login required)

View Item View Item