In vitro antibacterial activity of prenylated guanidine alkaloids from Pterogyne nitens and synthetic analogues

Coqueiro, Aline, Regasini, Luis Octávio, Stapleton, Paul, da Silva Bolzani, Vanderlan and Gibbons, Simon (2014) In vitro antibacterial activity of prenylated guanidine alkaloids from Pterogyne nitens and synthetic analogues. Journal of Natural Products, 77 (8). pp. 1972-1975. ISSN 0163-3864

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Abstract

The present investigation deals with the antibiotic activity of eight natural guanidine alkaloids and two synthetic analogues against a variety of clinically relevant methicillin-resistant Staphylococcus aureus strains. Galegine (1) and pterogynidine (2) were the most potent compounds, with a minimum inhibitory concentration of 4 mg/L, to all tested strains. The preliminary chemical features correlating to anti-MRSA activity showed that the size of the side chain and the substitution pattern in the guanidine core played a key role in the antibacterial activity of the imino group. Guanidine alkaloids 1 and 2 are promising molecular models for further synthetic derivatives and, thus, for medicinal chemistry studies.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 14 Jul 2020 23:51
Last Modified: 14 Jul 2020 23:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/76062
DOI: 10.1021/np500281c

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