Bioactive acetophenones from Plectranthus venteri

Maree, Johanna E., Khondkar, Proma, Kwapong, Awo A., Oyedemi, Blessing M., Aljarba, Tariq M., Stapleton, Paul, Viljoen, Alvaro M. and Gibbons, Simon (2014) Bioactive acetophenones from Plectranthus venteri. Phytochemistry Letters, 10. cxli-cxliv. ISSN 1874-3900

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In a project to investigate the chemistry of South African Plectranthus species, from the dichloromethane extract of the aerial parts of Plectranthus venteri, we isolated two known natural product acetophenones, namely 2-hydroxy-3,4,5,6-tetramethoxy-acetophenone (1) and 2-hydroxy-4,5,6-trimethoxy-acetophenone (2). Structures were assigned using NMR spectroscopy and HRTOFESIMS. Compound 1 was previously synthesised as a precursor to the polymethoxylated flavone nobiletin. The acetophenones exhibited remarkable inhibitory activities against the transfer of the IncW plasmid R7K in a bacterial plasmid transfer inhibition assay.

Item Type: Article
Uncontrolled Keywords: acetophenones,bacterial plasmid transfer inhibition,lamiaceae,plectranthus venteri,biotechnology,biochemistry,agronomy and crop science,plant science ,/dk/atira/pure/subjectarea/asjc/1300/1305
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 14 Jul 2020 23:50
Last Modified: 22 Oct 2022 06:28
DOI: 10.1016/j.phytol.2014.10.021

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