The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant

Gibbons, Simon and Udo, E. E. (2000) The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant. Phytotherapy Research, 14 (2). pp. 139-140. ISSN 0951-418X

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Abstract

As part of a screening programme to identify modulators of multidrug efflux in methicillin resistant Staphyloccocus aureus (MRSA), we have validated our assays using the antihypertensive plant alkaloid reserpine. Clinical isolates of MRSA were resistant to tetracycline and shown to possess the tet(K) determinant which encodes for the Tet(K) efflux protein, which conferred high level resistance to tetracycline (MIC = 128 μg/mL). In the presence of reserpine, a known inhibitor of multidrug resistance (mdr) efflux pumps, this MIC was significantly reduced (MIC = 32 μg/mL). Copyright (C) 2000 John Wiley and Sons, Ltd.

Item Type: Article
Uncontrolled Keywords: efflux,mdr,mrsa,multidrug resistance,tet(k),pharmacology ,/dk/atira/pure/subjectarea/asjc/3000/3004
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 10 Jul 2020 00:07
Last Modified: 10 Jul 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/76001
DOI: 10.1002/(SICI)1099-1573(200003)14:2<139::AID-PTR608>3.0.CO;2-8

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