Ostruthin: An Antimycobacterial Coumarin from the Roots of Peucedanum ostruthium

Schinkovitz, Andreas, Gibbons, Simon, Stavri, Michael, Cocksedge, Michael J. and Bucar, Franz (2003) Ostruthin: An Antimycobacterial Coumarin from the Roots of Peucedanum ostruthium. Planta Medica, 69 (4). pp. 369-371. ISSN 0032-0943

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Abstract

Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 10 Jul 2020 00:07
Last Modified: 10 Jul 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/75993
DOI: 10.1055/s-2003-38876

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