Pangelin, an Antimycobacterial Coumarin from Ducrosia anethifolia

Stavri, Michael, Mathew, K. Thomas, Bucar, Franz and Gibbons, Simon (2003) Pangelin, an Antimycobacterial Coumarin from Ducrosia anethifolia. Planta Medica, 69 (10). pp. 956-959. ISSN 0032-0943

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The aerial parts of Ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin (1) and the prenylated furanocoumarin pangelin {5-[2′′(R)-hydroxy-3′′-methyl-3′′-butenyloxy]furocoumarin} (2). Their structures were determined by extensive 1- and 2-dimensional NMR studies. Compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely Mycobacterium fortuitum, M. aurum, M. phlei and M. smegmatis and minimum inhibitory concentration (MIC) values ranged from 64 - 128 μg/mL. Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full 1H- and 13C-NMR data for these natural products.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 10 Jul 2020 00:07
Last Modified: 22 Oct 2022 06:27
DOI: 10.1055/s-2003-45109

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