Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)

Gibbons, Simon, Leimkugel, Julia, Oluwatuyi, Moyo and Heinrich, Michael (2003) Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA). Phytotherapy Research, 17 (3). pp. 274-275. ISSN 0951-418X

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Abstract

In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms. Copyright (C) 2003 John Wiley Sons, Ltd.

Item Type: Article
Uncontrolled Keywords: benzo[c]phenanthridine alkaloids,chelerythrine,efflux,mrsa,nor(a),msr(a),tet(k),multidrug resistance,mdr,in-vitro
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 10 Jul 2020 00:07
Last Modified: 10 Jul 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/75991
DOI: 10.1002/ptr.1112

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